G4251

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G4251

Sigma-Aldrich

 

L-Glutathione reduced

≥98.0%

Synonym:γ-L-Glutamyl-L-cysteinyl-glycine, GSH
Amino Acid Sequence:γ-Glu-Cys-Gly
CAS Number:70-18-8
Linear Formula:H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Molecular Weight:307.32
Beilstein Registry Number:1729812
EC Number:200-725-4
MDL number:MFCD00065939
PubChem Substance ID:24895164

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Description

Frequently Asked QuestionsLive Chat and Frequently Asked Questions are available for this Product.
ApplicationMay be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose.
Biochem/physiol ActionsEndogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents.
Packaging10 mg in autosmp vl

Properties

assay≥98.0%
mp192-195 °C (dec.)(lit.)
storage temp.2-8°C

Safety

Personal Protective EquipmentEyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
WGK Germany2
RTECSMC0556000

References

referencePompella, A., et al., The changing faces of glutathione, a cellular protagonist. Biochem. Pharmacol. 66, 1499-1503, (2003)
 Pastore, A., et al., Analysis of glutathione: implication in redox and detoxification. Clin. Chim. Acta 333, 19-39, (2003)
 Townsend, D.M., and Tew, K.D., The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene 22, 7369-7375, (2003)
MerckMerck 13,4488
BeilsteinBeil. 4,IV,3165
 FT-IR 1 (1), 787:D / FT-IR 2 (1), 1334:C / FT-NMR 1 (1), 1283:B / IR-Spectra (2), 414:G / IR-Spectra (3), 467:F / RegBook 1 (1), 919:L / Sax 6, 1478 / Sigma FT-IR 1 (1), 359:B / Structure Index 1, 143:B:1